Description of Research Activity 

Our scientific interest is mainly aimed at performing a structural and functional characterization of the ATP and Ubiquitin dependent proteolytic proteasomal system (UPS). For this purpose we utilize biochemical, molecular and cellular biology methods and approaches. Specifically, we investigate the role of the UPS in maintaining cellular homeostasis both in physiological (e.g. during plasmacells differentiation; in the context of Endoplasmic Reticulum Associated Degradation –ERAD-; MHC class I antigen presentation; cooperation between UPS and autophagy and molecular chaperones; aging) and pathological conditions (e.g. haematological – Multiple Myeloma and Systemic Amyloidosis – and solid (e.g. Feline and Canine Fibrosarcoma, Osteosarcoma and Mammary Carcinoma) malignancies; Neurodegenerative diseases – Parkinson and Amyotrophic lateral sclerosis).

Staff of the Unit

Paolo CASCIO	Associate Professor	paolo.cascio@unito.it
Silvia MIOLETTI	Assistant Professor	silvia.mioletti@unito.it
Fulvia CERRUTI	Technician	fulvia.cerruti@unito.it